Formate → HCID 12918095, compound

Participants

Reaction Steps

A solution of 4-amino-6-(cyclohexylamino)-5-(formylamino)-2-(methylthio)pyrimidine (25.0 g., 0.088 mole) or a mole equivalent of the formate salt thereof in 125 ml. ethanol and 500 ml. 1 N sodium hydroxide is refluxed for a 4 hr. period, cooled in an ice-bath, and then filtered affording 14.1 g. (61%) of yellow material. Crystallization from ethanol gives 6-amino-9-cyclohexyl-2-(methylthio)purine as off-white crystals, m.p. 222°-224°.

Provenance & Evidence