HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 1-Benzyl-3,4-epoxy-4-phenyl-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 6-Phenyl-7-oxa-3-azabicyclo[4.1.0]heptane | HCID 12929375 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 1-Benzyl-3,4-epoxy-4-phenyl-piperidine | HCID 12929376 | — |
Reaction Steps
22.5 Ml of benzyl bromide was added dropwise to a stirred solution of 32.3 g of 3,4-epoxy-4-phenylpiperidine and 38.1 ml of triethylamine in 254 ml of benzene. A precipitate appeared during the addition. The whole reaction mixture was then stirred at room temperature for three hours. The residual solid was removed by filtration and the solvent evaporated to give 53.4 g of 1-benzyl-3,4-epoxy-4-phenyl-piperidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04286095 |
| Source dataset | uspto-grants-1981_08 |
| ORD ID | ord-d08fcdc7e05c45b5aab61d664b25a1aa |
| Source note | uspto-grants-1981_08 |