Ethyl 4-{4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl}-alpha,alpha-dimethylbenzeneacetate hydrochloride → Ethyl 4-[3-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxypropyl]-alpha,alpha-dimethylbenzeneacetate hydrochloride

HRID 895080Notes

Reaction equation

HRID 895080 reaction equation
[ClH:1].[C:2]1([C:8]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[C:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][C:17]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([CH3:32])([CH3:31])[C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:21][CH:20]=3)=[O:18])[CH2:11][CH2:10]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[OH:40]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1CCN(CCCC(C2C=CC(C(C)(C)C(OCC)=O)=CC=2)=O)CC1>>[ClH:1].[OH:40][C:8]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)([C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1)[CH:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][CH:17]([C:19]2[CH:20]=[CH:21][C:22]([C:25]([CH3:31])([CH3:32])[C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:23][CH:24]=2)[OH:18])[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 12939646Ethyl 4-{4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl}-alpha,alpha-dimethylbenzeneacetate hydrochlorideHCID 86737529Ethyl 4-[3-[4-(diphenylmethylene)-1-piperidinyl]-1-oxopropyl]-alpha,alpha-dimethylbenzene acetate hydrochloride

Product 1

HCID 20572717Ethyl 4-[3-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxypropyl]-alpha,alpha-dimethylbenzeneacetate hydrochloride

Procedure

When in the procedure of Example 2 an appropriate amount of ethyl 4-[3-[4-(diphenylmethylene)-1-piperidinyl]-1-oxopropyl]-α,α-dimethylbenzene acetate hydrochloride is substituted for ethyl 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-α,α-dimethylbenzeneacetate hydrochloride, ethyl 4-[3-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxypropyl]-α,α- dimethylbenzeneacetate hydrochloride is obtained.

Sources & evidence

ORD record
ord-bf95ea2f8d8b4c5fb77f5d7de02b9506
Source dataset
uspto-grants-1981_08
Patent number
US04285957

Reaction notes

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