Water → HCID 20810218, compound

Participants

Reaction Steps

712 mg (2.21 mmol) of (2R)-methyl-3-oxo-6-(2,2,3,3,3,-pentafluoropropylimino-methyl-3,4-dihydro-2H-1,4-benzoxazine is dissolved in 30 ml of methanol and mixed with 83.6 mg (2.21 mmol) of sodium borohydride. After stirring overnight at room temperature, the batch is added to water and shaken three times with ethyl acetate. The combined organic phases are washed with saturated sodium chloride solution, dried and spun in. After chromatography on silica gel (mobile solvent: ethyl acetate/hexane), 396.7 mg (55%) of the desired compound is obtained.

Provenance & Evidence