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Thiomorpholine (728 mg, 7.06 mmol) was added to a stirring solution of 3,4,5-trifluoronitro benzene (500 mg, 2.82 mmol) in acetonitrile (15 mL) and the reaction mixture was refluxed for 5 h. Evaporation of the solvent in a rotavapor under reduced pressure left a pasty mass which was dissolved in ethyl acetate (50 mL). Ethyl acetate portion was washed with water (30 mL×2) followed by brine (30 mL) and dried over sodium sulfate. Removal of volatiles yielded the title compound as yellow solid (650 mg, 85%).

1. temperaturethe reaction mixture was refluxed for 5 h
2. customEvaporation of the solvent in a rotavapor under reduced pressure
3. waitleft a pasty mass which
4. dissolutionwas dissolved in ethyl acetate (50 mL)
5. washEthyl acetate portion was washed with water (30 mL×2)
6. dry with materialdried over sodium sulfate
7. customRemoval of volatiles