Boron tribromide → HCID 10236221, compound

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Reaction Steps

The title compound was prepared by reacting 6-(3-fluoro-4-methoxyphenyl)-2-naphthol (600 mg, 2.24 mmol) with boron tribromide (6.27 mL of 1.0 M solution in CH2Cl2, 6.27 mmol) according to method D to yield 385 mg (68%) of a yellowish solid: mp 216-219° C.; 1H NMR (DMDO-d6): δ 7.03-7.13 (3H, m), 7.43 (1H, dd, J=8.37 Hz, J=1.77 Hz), 7.58 (1H, dd, J=12.92 Hz, J=2.13 Hz), 7.68 (1H, dd, J=8.68 Hz, J=1.61 Hz), 7.74 (1H, d, J=8.68 Hz), 8.03 (1H, s), 9.79 (1H, s), 9.98 (1H, s); MS (ESI) m/z 253 (M−H)−. Anal. for C16H11FO2.0.13H2O:

Provenance & Evidence