HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromo-2-naphthalenol → 6-Bromo-1-chloronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromo-2-naphthalenol | HCID 27144 | — |
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-Bromo-1-chloronaphthalen-2-ol | HCID 22048159 | — |
Reaction Steps
The title compound was prepared by reacting 6-bromo-2-naphthol (3 g, 13.4 mmol) and NCS (2.47 g, 18.5 mmol) in THF (50 mL) according to method C to yield 2.2 g (64%) of yellow solid: 1H NMR (DMDO-d6): δ 7.34 (1H, d, J=8.87 Hz), 7.69 (1H, dd, J=1.75 Hz, J=6.09 Hz), 7.79 (1H, d, J=8.96 Hz), 7.96 (1H, d, J=9.03 Hz), 8.17 (1H, d, J=1.75 Hz), 10.68(1H, s); MS (ESI) m/z255/2571259 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06914074B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-5928d184602341dd99bb5267293f95ed |
| Source note | uspto-grants-2005_07 |