HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 8-Bromo-7-hydroxy-3-(4-methoxyphenyl)-1-naphthonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 7-Hydroxy-3-(4-methoxyphenyl)-1-naphthonitrile | HCID 11254366 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 8-Bromo-7-hydroxy-3-(4-methoxyphenyl)-1-naphthonitrile | HCID 11187337 | — |
Reaction Steps
The title compound was prepared by reacting 7-hydroxy-3-(4-methoxyphenyl)-1-naphthonitrile (0.160 g, 0.58 mmol) with NBS (0.12 g, 0.70 mmol) in THF (10 mL) according to method C to yield 0.080 g (39%) of a yellow solid: mp 145-146° C.; 1H NMR (DMSO-d6): δ 3.83 (3H, s), 7.08 (2H, d, J=8.79 Hz), 7.42 (1H, d, J=8.79 Hz), 7.84 (2H, d, J=8.79 Hz), 8.04 (1H, d, J=8.79 Hz), 8.42 (1H, d, J=1.95 Hz), 8.53 (1H, d, J=1.95 Hz), 11.21 (1H, s); MS (ESI) m/z 354/356 (M+H+; MS (ESI) m/z 352/354 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06914074B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-73371387546c4dd08f8cea001f1e61e5 |
| Source note | uspto-grants-2005_07 |