3-Methoxybenzaldehyde → 3-Methyl-N-[2-amino-1-{3-methoxyphenyl}-2-oxoethyl]-N-(4-methylbenzyl)pyrazine-2-carboxamide

HRID 895289Notes

Reaction equation

HRID 895289 reaction equation
ClC1C(C([N:12]([CH:21]([C:25]2[CH:34]=[CH:33][C:28]3OC[CH2:31][O:32][C:27]=3[CH:26]=2)[C:22]([NH2:24])=[O:23])[CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=2)=O)=NC(SC)=NC=1.[CH3:35][C:36]1[C:37]([C:42]([OH:44])=O)=[N:38][CH:39]=[CH:40][N:41]=1.COC1C=C(C=CC=1)C=O>>[CH3:35][C:36]1[C:37]([C:42]([N:12]([CH:21]([C:25]2[CH:34]=[CH:33][CH:28]=[C:27]([O:32][CH3:31])[CH:26]=2)[C:22]([NH2:24])=[O:23])[CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=2)=[O:44])=[N:38][CH:39]=[CH:40][N:41]=1

Participants

4

Reactant 3

HCID 115693-MethoxybenzaldehydeHCID 100061165-Chloro-2-methylthio-N-[2-amino-1-{1,4-benzodioxan-6-yl}-2-oxoethyl]-N-(4-methylbenzyl)pyrimidine-4-carboxamideHCID 131534683-Methylpyrazine-2-carboxylic acid

Product 1

HCID 223861973-Methyl-N-[2-amino-1-{3-methoxyphenyl}-2-oxoethyl]-N-(4-methylbenzyl)pyrazine-2-carboxamide

Procedure

This was prepared in the same manner as the product from example 242 using 3-methylpyrazine-2-carboxylic acid (JOC, 2002, p556) and 3-methoxybenzaldehyde as the acid and aldehyde components to give the title compound as a foam, 0.5 g, (63%).

Sources & evidence

ORD record
ord-e61f9088f781425fad7967f41297447e
Source dataset
uspto-grants-2005_07
Patent number
US06914160B1

Reaction notes

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