Cyclohexene → 6-Methoxy-2-morpholin-4-ylpyrid-3-ylamine

HRID 895304Notes

Reaction equation

HRID 895304 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[C:7]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[C:6]([N+:15]([O-])=O)=[CH:5][CH:4]=1.C1CCCCC=1>[Pd].C(O)C>[CH3:1][O:2][C:3]1[N:8]=[C:7]([N:9]2[CH2:10][CH2:11][O:12][CH2:13][CH2:14]2)[C:6]([NH2:15])=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 8079CyclohexeneHCID 28264174-(6-Methoxy-3-nitropyrid-2-yl)morpholine

Product 1

HCID 120934016-Methoxy-2-morpholin-4-ylpyrid-3-ylamine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

6.19 g (0.026 mol) of the product 4-(6-methoxy-3-nitropyrid-2-yl)morpholine synthesized according to the above procedure, 50 ml of ethanol, 20 ml of cyclohexene and 2 g of palladium-on-charcoal were placed in a fully equipped round-bottomed flask.

Sources & evidence

ORD record
ord-92bfd378b5734e0d89f5e61d774fbdaa
Source dataset
uspto-grants-2005_07
Patent number
US06916345B2

Reaction notes

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