Glycerol → Mannitol

HRID 895307Notes

Reaction equation

[OH2:1].COC1C(N2C[C@@H]3[C@@H](CCCN3)C2)=C(F)C=C2[C:20]([C:22]([C:28]([OH:30])=O)=CN(C3CC3)C=12)=[O:21].[OH:31][CH2:32][CH:33]([CH2:35][OH:36])[OH:34]>>[CH2:32]([OH:31])[C@H:33]([C@H:35]([C@@H:28]([C@@H:22]([CH2:20][OH:21])[OH:1])[OH:30])[OH:36])[OH:34]

Participants

Reactant 3

HCID 753Glycerol

HCID 962Water

HCID 152946Moxifloxacin

Product 1

HCID 6251Mannitol

Procedure

For preparation, water for injection is initially charged in a 201 glass bottle, and moxifloxacin and glycerol are dissolved therein with stirring at RT. The solution has a pH of about 4.4. The solution is then filtered through a filter having a pore size of 0.22 μm into an enamel-coated intermediate container, and in each case 100 ml are filled into infusion bottles. The filled bottles are sterilized in an autoclave at 121° C. for 20 min.

Workup

dissolutionare dissolved
filtrationThe solution is then filtered through a filter
additionin each case 100 ml are filled into infusion bottles

Sources & evidence

ORD record: ord-7076518f57d6474cbf1648126efcb90b
Source dataset: uspto-grants-2005_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06916484B1

Reaction notes

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