Ammonia → HCID 21867934, compound

Participants

Reaction Steps

Thirty grams (0.11 mol) of N-(4-anilinophenyl)-3-oxo butanamide was dissolved in 300 ml of toluene. This was mixed with 30 g. (1.8 mol) of anhydrous ammonia, Raney nickel catalyst, and 800 psi of hydrogen gas at a temperature of 70° C. for 2 hours. The catalyst was removed and the solvent stripped off under vacuum. Purification was done by flash chromatography and recrystallization from hot toluene. The product was obtained in a yield of 16 g. with a melting point of 130-132° C.

Provenance & Evidence