1-Piperazinecarboxylic acid, ethyl ester → HCID 69795127, compound

Participants

Reaction Steps

In a round-bottomed flask fitted with a reflux condenser and a thermometer, 15 g (125 mmoles) of (R)-phenyloxirane, 19.75 g (125 mmoles, 18.3 ml) of ethyl-N-piperazine carboxylate, and 80 ml of ethyl alcohol were introduced. The mixture was heated at reflux for 3 hours. Volatile substances were removed under reduced pressure and the resulting mixture was purified by chromatography on silica gel (eluent: CH2Cl2/MeOH/aqueous ammonia 98.5/1.5/0.5 (v/v/v)), affording 8.8 g of (S)-4-(2-Hydroxy-1-phenyl-ethyl)-piperazine-1-carboxylic acid ethyl ester (compound 2) as a colorless oil. Yield: 25%.

Provenance & Evidence