Potassium Hydroxide → HCID 22353140, compound

Participants

Reaction Steps

In a round-bottomed flask were introduced {4-[1-(2-Amino-phenyl)-2-(3,5-bis-trifluoromethyl-benzyloxy)-ethyl]-piperazin-1-yl}-acetic acid methyl ester (compound 323; 1.3 g, 2.5 mmoles), KOH (0.35 g, 6.3 mmoles) and MeOH (20 ml). The reaction mixture was stirred at room temperature for 6 hours. MeOH was removed under reduce pressure and the residue was taken up in water. The pH was adjusted to 6 and the solution was extracted with CH2Cl2. The combined organic layers were dried over MgSO4 and concentrated. The residue (1.1 g, 88%) was recrystallized from diethylether to give {4-[1-(2-Amino-phenyl)-2-(3,5-bis-trifluoromethyl-benzyloxy)-ethyl]-piperazin-1-yl}-acetic acid (compound 324; 0.75 g, 60%) as white needles.

Provenance & Evidence