Hydrochloric Acid → HCID 9934105, compound

Participants

Reaction Steps

To a solution of the ester 1-3 (180 mg, 0.37 mmol) in THF (20 mL) and water (20 mL) at room temperature was added 1N LiOH solution (5 mL, 5 mmol) and the mixture stirred for 16 hr. The mixture was neutralized with 1N HCl and the solvent removed. Column chromatography of the residue (silica gel; CHCl3/EtOAc/MeOH 8:1:1) gave 1-4 as a white solid.

Provenance & Evidence