反应详情

4-[3-(5-Nitro-biphenyl-2-yloxy)-propyl]-morpholine (u, 400 mg, 1.1 mmol) was dissolved in 10 mL ethanol and hydrogenated at 1 atm. using 10% Pd—C as a catalyst. After the reaction was allowed to stir overnight, the reaction mixture was filtered and the solvent was evaporated. The residue was purified by silica gel chromatography (eluent: 5% methanol/DCM) to afford 160 mg 6-(3-morpholin-4-yl-propoxy)-biphenyl-3-ylamine (v): m/e: 312.18, MS (ES+): 313.2.

1. filtrationthe reaction mixture was filtered
2. customthe solvent was evaporated
3. customThe residue was purified by silica gel chromatography (eluent: 5% methanol/DCM)