Benzoyl chloride → Aniline

HRID 895382Notes

Reaction equation

HRID 895382 reaction equation
C(=NC(N)=S)=O.C(Cl)(=O)[C:8]1[CH:13]=[CH:12]C=[CH:10][CH:9]=1.Cl[C:17]1[CH:22]=[C:21](Cl)[CH:20]=[CH:19][C:18]=1[CH:24]([NH:31]C([NH:42][C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1)=NC(C1C=CC=CC=1)=O)[CH2:25]N1C=CN=C1>>[NH2:42][C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1.[C:25]1([CH:24]([NH2:31])[C:18]2[CH:17]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:12]=[CH:13][CH:8]=[CH:9][CH:10]=1

Participants

5

Reactant 3

HCID 7412Benzoyl chlorideHCID 15908598HCID 15908598, compoundHCID 178523892HCID 178523892, compound

Product 2

HCID 6115AnilineHCID 7036Benzhydrylamine

Procedure

N-[1-(2,4-Dichlorophenyl)-2-(imidazol-1-yl)-ethyl]-N′-phenyl)carbonyl thiourea. Compound A was prepared by following the procedure of Example 190, Step A, except benzoyl chloride was used instead of 4-chlorobenzoyl chloride. B. N-[1-(2,4-Dichlorophenyl)-2-(imidazol-1-yl)-ethyl]—N′-phenyl-N″-phenylcarbonylguanidine. Step B of Example 190 was followed using Compound A, above, and aniline (instead of diphenylmethylamine) to obtain Example 191. MS (ES): m/z 478 [M+H]+.

Sources & evidence

ORD record
ord-49ab3c0fb15146ed8515e83e9d9d940f
Source dataset
uspto-grants-2005_07
Patent number
US06916813B2

Reaction notes

Loading…