2-Aminothiazole → HCID 178478541, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 2-aminothiazole (100 mg) in acetonitrile (3 mL) was added thiocarbonyl dimidazole (180 mg, 1.0 mmol). The mixture was allowed to stir at rt for 2 h and at 65° C. for 5 h, and then 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethylamine (250 mg, 1.0 mmol) was added. This was allowed to stir for 5 h at 65° C. The mixture was cooled to rt, and diphenylmethylamine was added, followed by TEA and mercuric chloride. The suspension was allowed to stir at rt for 3 h and filtered. The filtrate was concentrated and the residue purified by column chromatography (EtOAc, MeOH, NH4OH; 90:10:0.1) to give after conversion to HCT salt, the title compound as a yellow solid (100 mg). MS (ES): m/z 547 [M+H]+.

Provenance & Evidence