HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Naphthalenesulfonyl chloride → 3-(1,2,3,5,8,8a-Hexahydro-7-indolizinyl)-1-(1-naphthalenesulfonyl)-6-azaindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Naphthalenesulfonyl chloride | HCID 66560 | — |
| Reactant | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| Reactant | 3-(1,2,3,5,8,8a-Hexahydro-7-indolizinyl)-1H-6-azaindole | HCID 9881227 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(1,2,3,5,8,8a-Hexahydro-7-indolizinyl)-1-(1-naphthalenesulfonyl)-6-azaindole | HCID 9888881 | — |
Reaction Steps
from 3-(1,2,3,5,8,8a-hexahydro-7-indolizinyl)-1H-6-Azaindole (12 mg, 0.055 mmol), 1-naphthalenesulfonyl chloride (20.9 mg, 0.1 mmol) and 1M NaN(TMS)2 (100 μL, 0.10 mmol) in THF (1 mL) at RT.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06916818B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-ec05ef8e6eb64829b8129aa0e7131137 |
| Source note | uspto-grants-2005_07 |