HCID 22378694, compound → HCID 22378989, compound

Participants

Reaction Steps

N-{2-[(6-Chloro-2-phenylpyrimidin-4-yl)amino]ethyl}acetamide (100 mg) was dissolved in ethylenediamine (5 ml) and the stirred under reflux for 4 hrs. The reaction mixture was then cooled to ambient temperature and the solvent removed in vacuo. Purification via flash chromatography on silica gel eluting first with a mixture of ethyl acetate and methanol (9:1 v/v) then a mixture of ethyl acetate, methanol and ammonium hydroxide (80:20:2 v/v/v) to furnish the title compound (89 mg).

Provenance & Evidence