HCID 22379071, compound → HCID 22353380, compound

Participants

Reaction Steps

N-{2-[(6-Chloro-5-methyl-2-phenylpyrimidin-4-yl)amino]ethyl}acetamide (2.0 g) was dissolved in ethylenediamine (40 ml) and heated with stirring to reflux for 21 hrs. After cooling to ambient temperature the solution was evaporated onto silica gel (50 g). Purification via flash chromatography on silica gel eluting with a mixture of ethyl acetate, methanol and ammonium hydroxide (80:20:5 v/v/v) furnished the title compound (1.83 g).

Provenance & Evidence