HCID 22353305, compound → HCID 22378879, compound

Participants

Reaction Steps

N-(2-{[6-Chloro-2-(4-chlorophenyl)pyrimidin-4-yl]amino}ethyl)acetamide (0.90 g) was dissolved in ethylenediamine (20 ml) and heated with stirring to reflux for 18 hrs. After cooling to ambient temperature the solution was evaporated onto silica gel. Purification via flash chromatography on silica gel eluting with increasingly polar solvent systems from ethyl acetate to methanol furnished the title compound (0.67 g).

Provenance & Evidence