HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-Nitro-2-(trifluoromethyl)pyridin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Chloro-5-nitro-2-(trifluoromethyl)pyridine | HCID 22380051 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Nitro-2-(trifluoromethyl)pyridin-4-amine | HCID 22380026 | 96% |
Reaction Steps
Ammonia gas is bubbled through a solution of 2-trifluoromethyl-4-chloro-5-nitro-pyridine (4.12 g, 18.23 mmol) in anhydrous THF at room temperature for 3 h. Removal of solvent under reduced pressure affords 5-nitro-2-trifluoromethyl-pyridin-4-ylamine (3.6 g, 96%); 1H NMR (300 MHz, CDCl3): δ 7.15 (s, 1H), 9.15 (s,1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06916819B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-f434f309f2114b88a54f044210974e25 |
| Source note | uspto-grants-2005_07 |