Methanol → 1-(4-Diethylcarbamoylphenyl)-1-(2-methoxyphenyl)methyl acetate

HRID 895609Notes

Reaction equation

HRID 895609 reaction equation
[CH2:1]([N:3]([CH2:22][CH3:23])[C:4]([C:6]1[CH:11]=[CH:10][C:9]([CH:12]([OH:21])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])=[CH:8][CH:7]=1)=[O:5])[CH3:2].[C:24](OC(=O)C)(=[O:26])[CH3:25].CO>N1C=CC=CC=1>[C:24]([O:21][CH:12]([C:9]1[CH:8]=[CH:7][C:6]([C:4](=[O:5])[N:3]([CH2:1][CH3:2])[CH2:22][CH3:23])=[CH:11][CH:10]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20])(=[O:26])[CH3:25]

Participants

5

Reactant 3

HCID 887MethanolHCID 7918Acetic AnhydrideHCID 697198441-(4-Diethylcarbamoylphenyl)-1-(2-methoxyphenyl)methyl alcohol

Product 1

HCID 697188771-(4-Diethylcarbamoylphenyl)-1-(2-methoxyphenyl)methyl acetate

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1-(4-Diethylcarbamoylphenyl)-1-(2-methoxyphenyl)methyl alcohol (14.14 g) was dissolved in pyridine (280 ml), added with acetic anhydride (140 ml) with ice cooling and stirred at room temperature for 15 hours. After the reaction mixture was added with methanol (140 ml) with ice cooling and stirred at room temperature for 10 minutes, the solvent was evaporated under reduced pressure to obtain 1-(4-diethylcarbamoylphenyl)-1-(2-methoxyphenyl)methyl acetate.

Workup

  1. stirringstirred at room temperature for 10 minutes
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-183b4a15f512442bb196df8442e482ea
Source dataset
uspto-grants-2005_07
Patent number
US06916822B2

Reaction notes

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