1,4-Dioxane → HCID 22380705, compound

HRID 895614Notes

Reaction equation

HRID 895614 reaction equation
[CH2:1]([N:3]([CH2:25][CH3:26])[C:4]([C:6]1[CH:24]=[CH:23][C:9]([CH2:10][C:11]2[CH:22]=[CH:21][CH:20]=[CH:19][C:12]=2[O:13]CC(O)CO)=[CH:8][CH:7]=1)=[O:5])[CH3:2].I([O-])(=O)(=O)=O.[Na+].[O:33]1CCO[CH2:35][CH2:34]1>O>[CH2:25]([N:3]([CH2:1][CH3:2])[C:4]([C:6]1[CH:24]=[CH:23][C:9]([CH2:10][C:11]2[CH:22]=[CH:21][CH:20]=[CH:19][C:12]=2[O:13][C:34](=[O:33])[CH3:35])=[CH:8][CH:7]=1)=[O:5])[CH3:26]

Participants

5

Reactant 3

HCID 312751,4-DioxaneHCID 22380685HCID 22380685, compoundHCID 23667635Sodium periodate

Product 1

HCID 22380705HCID 22380705, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

1-[2-(4-Diethylcarbamoylbenzyl)phenoxy]-2,3-dihydroxypropane (263 mg) was dissolved in a mixed solution of dioxane (2.6 ml) and water (2.6 ml), added with sodium periodate (362 mg) and stirred at room temperature for 1 hour. The reaction mixture was added with water (10 ml) and extracted twice with dichloromethane (10 ml). The organic layer was dried over anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure to obtain 239 mg of the title compound. Yield: 100%.

Workup

  1. extractionextracted twice with dichloromethane (10 ml)
  2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  3. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-9c6b24f6e8e54177aa1a5aa1e7d98833
Source dataset
uspto-grants-2005_07
Patent number
US06916822B2

Reaction notes

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