Methanol → 1-[4-(4,4-Dimethyloxazolin-2-yl)phenyl]-1-(2-methoxyphenyl)methyl acetate

HRID 895646Notes

Reaction equation

HRID 895646 reaction equation
[CH3:1][C:2]1([CH3:23])[CH2:6][O:5][C:4]([C:7]2[CH:12]=[CH:11][C:10]([CH:13]([OH:22])[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[O:20][CH3:21])=[CH:9][CH:8]=2)=[N:3]1.[C:24](OC(=O)C)(=[O:26])[CH3:25].CO>N1C=CC=CC=1>[C:24]([O:22][CH:13]([C:10]1[CH:9]=[CH:8][C:7]([C:4]2[O:5][CH2:6][C:2]([CH3:23])([CH3:1])[N:3]=2)=[CH:12][CH:11]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[O:20][CH3:21])(=[O:26])[CH3:25]

Participants

5

Reactant 3

HCID 887MethanolHCID 7918Acetic AnhydrideHCID 697206701-[4-(4,4-Dimethyloxazolin-2-yl)phenyl]-1-(2-methoxyphenyl)methyl alcohol

Product 1

HCID 223807461-[4-(4,4-Dimethyloxazolin-2-yl)phenyl]-1-(2-methoxyphenyl)methyl acetate

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1-[4-(4,4-Dimethyloxazolin-2-yl)phenyl]-1-(2-methoxyphenyl)methyl alcohol (100 mg) was dissolved in pyridine (0.4 ml), added with acetic anhydride (0.25 ml) with ice cooling and stirred at room temperature for 4 hours. After the reaction mixture was added with methanol (0.25 ml) with ice cooling and stirred at room temperature for 10 minutes, the solvent was evaporated under reduced pressure to obtain 1-[4-(4,4-dimethyloxazolin-2-yl)phenyl]-1-(2-methoxyphenyl)methyl acetate.

Workup

  1. stirringstirred at room temperature for 10 minutes
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-a904841b26b14bbc8b1ee040bd12da8c
Source dataset
uspto-grants-2005_07
Patent number
US06916822B2

Reaction notes

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