反应详情

23.43 ml of 2-chlorotoluene and 26.6 g of 3-chloropropionyl chloride are mixed in 25 ml of carbon sulfide and 32 g of AlCl3 in 125 ml of carbon sulfide are added over 45 minutes. After stirring for 3 hours at RT, the solvent is evaporated and then 1 liter of water is added. The reaction medium is extracted with ether and then with benzene, and then the organic phase is washed with a saturated Na2CO3 solution and then with water. It is dried over Na2SO4 and then the residue is chromatographed on a silica column, eluting with an AcOEt/cyclohexane (5/95; v/v) mixture. 27.25 g of the expected compound are obtained.

1. customthe solvent is evaporated
2. addition1 liter of water is added
3. extractionThe reaction medium is extracted with ether
4. washwith benzene, and then the organic phase is washed with a saturated Na2CO3 solution
5. dry with materialIt is dried over Na2SO4
6. customthe residue is chromatographed on a silica column
7. washeluting with an AcOEt/cyclohexane (5/95; v/v) mixture