Ammonium Chloride → 4-Ethinyl-1,5-dimethyl-3-(trifluoromethyl)-1h-pyrazole

Participants

Reaction Conditions

Reaction Steps

1.27 g (5.67 mmol) of 4-(2-chloroethenyl)-1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazole are dissolved in 40 ml of dry THF and placed under a protective gas atmosphere. After the reaction solution has been cooled to 0° C., 1.91 g (17.0 mmol) of potassium tert-butoxide are introduced and, on completion of addition, the mixture is stirred at 20° C. for 3 h. After the end of the reaction, a saturated NH4Cl solution (25 ml) is added and extraction is effected twice with CH2C12. The combined organic phases are dried over MgSO4 and concentrated. The product is obtained as a solid in a 79% yield.

Provenance & Evidence