Potassium Carbonate → HCID 22380848, compound

Participants

Reaction Steps

A mixture of 3-methyl-2-o-tolyl-piperidine and 3-methyl-2-(2-methyl-cyclohexyl)-piperidine (330 mg), 2-chloro-N-(2-fluoro-benzyl)-N-indan-2-yl-acetamide (600 mg), and potassium carbonate (520 mg) in acetonitrile (10 ml) is heated at reflux for 16 hours. The reaction mixture is cooled, treated with water, and extracted with ethyl acetate. The combined extracts are washed with brine, dried over sodium sulfate, and concentrated in vacuo. The residue is purified by flash chromatography over silica gel (elution with 5% MeOH/CH2Cl2) to give 4-(2-fluoro-phenyl)-3-indan-2-yl-1-(3-methyl-2-o-tolyl-piperidin-1-yl)-butan-2-one (Compound 10) as a pale yellow oil. LCMS 471.3(MH+).

Provenance & Evidence