反应详情

The compound (t-butyl 2-fluoro-5-nitrobenzoate) (1.74 g) obtained in a previous production example, 6-cyano-2-naphthol (1.86 g) and potassium carbonate (8.2 g) were heated to 50° C. in N,N-dimethylformamide and reacted for 2 hours. After cooling to room temperature, water was added and extraction was performed with ethyl acetate. The ethyl acetate layer was washed with saturated saline and dried over magnesium sulfate, and the solvent was distilled off. The residue was purified by silica gel chromatography (300 g, hexane:ethyl acetate=5:1) to obtain 3.23 g of t-butyl 2-(6-cyano-2-naphthyloxy)-5-nitrobenzoate.

1. customreacted for 2 hours
2. extractionextraction
3. washThe ethyl acetate layer was washed with saturated saline
4. dry with materialdried over magnesium sulfate
5. distillationthe solvent was distilled off
6. customThe residue was purified by silica gel chromatography (300 g, hexane:ethyl acetate=5:1)