反应详情

温度

60 °C

The product of Step 1, Example 53B (1 eq) was weighed into a flask along with NaH2PO4 (12 eq), t-butyl alcohol (0.12 M), water (0.12 M), 2-methyl-2-butene (50 eq) and to this mixture was added NaO2Cl (11.8 eq) at 25° C. Reaction mixture was then heated at 60° C., 3 h and left overnight at 25° C. Workup with ethyl acetate/water followed by chromatographic purification and triturations with CH2Cl2/hexane (1:1) afforded the desired product in 57% yield.

1. customReaction mixture
2. customWorkup with ethyl acetate/water followed by chromatographic purification and triturations with CH2Cl2/hexane (1:1)