Dimethylformamide → HCID 11694578, compound

Participants

Reaction Steps

A total of 8.0 g of the concentrated residue containing 3-(3′-chlorophenyl)-2-methoxycarbonylpropionic acid prepared in Step B was dissolved in 32.8 g of 1,2-dichloroethane in an atmosphere of nitrogen gas, followed by addition of 11.8 g of thionyl chloride and 0.05 g of dimethylformamide. The mixture was stirred at 40° C. for 7 hours, from which 1,2-dichloroethane and unreacted thionyl chloride were removed under reduced pressure to yield 7.98 g of methyl 2-chloroformyl-3-(3′-chlorophenyl)-propionate. The NMR spectral data of this compound are shown below.

Provenance & Evidence