HCID 22382441, compound → HCID 58860068, compound

Participants

Reaction Steps

To a suspension of dichloro[(S)-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl][(S)-1,1′-bis(p-methoxyphenyl)-2-isopropylethane-1,2-diamine]ruthenium (II) (111 mg) and potassium-tert-butoxide (44.9 mg) in isopropanol (100 ml) was added (cyclopropyl)[2-(tert-butyldimethylsilyloxymethyl)phenyl]methanone (5.81 g) obtained in Step 2, and the mixture was subjected to medium pressure hydrogenation (5.0 kgf/cm2) at room temperature for 36 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:5) to give the title compound (5.82 g).

Provenance & Evidence