2-Methyl-6-(propan-2-yl)benzoyl chloride → HCID 69716544, compound

HRID 895923Notes

Reaction equation

C[O:2][C:3](=[O:26])[C@H:4]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:14](=[O:25])[N:15]([CH3:24])[C:16]([CH3:23])=[CH:17][C:18]=2[C:19]([F:22])([F:21])[F:20])=[CH:9][CH:8]=1)[NH2:5].[CH3:27][CH:28]([C:30]1[CH:38]=[CH:37][CH:36]=[C:35]([CH3:39])[C:31]=1[C:32](Cl)=[O:33])[CH3:29]>>[CH3:29][CH:28]([C:30]1[CH:38]=[CH:37][CH:36]=[C:35]([CH3:39])[C:31]=1[C:32]([NH:5][C@H:4]([C:3]([OH:2])=[O:26])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:14](=[O:25])[N:15]([CH3:24])[C:16]([CH3:23])=[CH:17][C:18]=2[C:19]([F:22])([F:20])[F:21])=[CH:9][CH:8]=1)=[O:33])[CH3:27]

Participants

Reactant 2

HCID 223820312-Methyl-6-(propan-2-yl)benzoyl chloride

HCID 69716007HCID 69716007, compound

Product 1

HCID 69716544HCID 69716544, compound

Procedure

N-[[2-(1-methylethyl)-6-methylphenyl]carbonyl]-4-[1,6-dimethyl-4-(trifluoromethyl)-2-oxo-3-pyridinyl]-L-phenylalanine was prepared from 4-[1,6-dimethyl-4-(trifluoromethyl)-2-oxo-3-pyridinyl]-L-phenylalanine methyl ester and 2-(1-methylethyl)-6-methylbenzoyl chloride using the general procedures described in example 33. ES-HRMS m/e calcd for C28H29F3N2O4 (M+Na) 537.1972. found 537.1977.

Sources & evidence

ORD record: ord-fd64d1aee3624e68941062a2951eb192
Source dataset: uspto-grants-2005_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06916933B2

Reaction notes

Loading…