Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Malononitrile | HCID 8010 | — |
| Reactant | 3,4-Dihydroxybenzaldehyde | HCID 8768 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Tyrphostin 23 | HCID 2052 | 86% |
Reaction Steps
To 11 g (80 mmol) of 3,4-dihydroxybenzaldehyde and 5.5 g (83 mmol) of malononitrile in 40 ml of ethanol, 7 drops of piperidine were added and the mixture was heated at 70° C. for 0.5-1 hour and then poured into water. The resulting solid precipitate was separated by filtration to give 12.7 g (86% yield) of a yellow solid, m.p. 225° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | USRE038761E1 |
|---|
| Source dataset | uspto-grants-2005_07 |
|---|
| ORD ID | ord-93870b60651140679cf983d95aded4d5 |
|---|
| Source note | uspto-grants-2005_07 |
|---|
