Sodium Hydroxide → 2-Nitrodibenzo[b,f][1,4]oxazepin-11(10H)-one

HRID 895973Notes

Reaction equation

HRID 895973 reaction equation
Cl[C:2]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[OH:13])=[O:5].[OH-].[Na+]>O>[N+:18]([C:15]1[CH:16]=[CH:17][C:2]2[O:13][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=3[NH:6][C:4](=[O:5])[C:3]=2[CH:14]=1)([O-:20])=[O:19]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 43061272-chloro-N-(2-hydroxyphenyl)-5-nitrobenzamide

Product 1

HCID 6206222-Nitrodibenzo[b,f][1,4]oxazepin-11(10H)-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Chloro-N-(2-hydroxy-phenyl)-5-nitrobenzamide (10 g, 34.1 mmol) was added to a solution of sodium hydroxide (1.5 g, 37.6 mmol) in water (300 mL) and the resultant solution heated at 90° C. for 6 hr. The precipitate was filtered and washed with 4×100 mL of water. Yield 8.4 g (96%).

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with 4×100 mL of water

Sources & evidence

ORD record
ord-8c4055e98dff4993ada81058e4253c77
Source dataset
uspto-grants-2005_07
Patent number
US06919328B1

Reaction notes

Loading…