反应详情

2-Amino-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one (Example 6, 54 mg, 0.24 mmol) was dissolved in methanol (10 mL) and thiophene-2-carboximidothioic acid phenyl ester hydrobromide (79 mg, 0.26 mmol) added. The reaction was stirred at room temperature for 4 hr. The solvent was evaporated and the residue recrystallized from a mixture of methanol and ether to give a yellow solid. The solid was washed several times with ether (84 mg, 0.20, 84%).

1. customThe solvent was evaporated
2. customthe residue recrystallized from a mixture of methanol and ether
3. customto give a yellow solid
4. washThe solid was washed several times with ether (84 mg, 0.20, 84%)