HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-(Trimethylsilyl)ethyl 3-bromo-2-thiophenecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-(Trimethylsilyl)ethanol | HCID 18013 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Bromothiophene-2-carboxylic acid | HCID 2739688 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | 2-(Trimethylsilyl)ethyl 3-bromo-2-thiophenecarboxylate | HCID 22349228 | — |
Reaction Steps
A solution of 3-bromothiophene-2-carboxylic acid (1 mmol) and SOCl2 (3 mmol) in 1 mL of dichloroethane was heated at 80° C. for 20 h and then the solvents evaporated. The residue was dissolved in 2 mL CH2Cl2 and mixed with triethylamine (3 mmol) and 2-(trimethylsilyl)ethanol (1.3 mmol) at rt for 12 h. Extractive isolation provided 2-(trimethylsilyl)ethyl 3-bromo-2-thiophenecarboxylate as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06919322B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-ef9af8e708cf467aabbc4a5be04e1462 |
| Source note | uspto-grants-2005_07 |