HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-Phenyl-2-(trimethylsilyl)acetylene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Iodobenzene | HCID 11575 | — |
| Reactant | Trimethylsilylacetylene | HCID 66111 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Phenyl-2-(trimethylsilyl)acetylene | HCID 137464 | — |
Reaction Steps
A solution of iodobenzene (1 mmole) in DMF (5 mL) was treated with trimethylsilylacetylene (2 mmole), Pd(PPh3)2Cl2 (0.035 mmole), CuI (0.08 mmole) and triethylamine (4 mmole), and the resulting reaction mixture was stirred under nitrogen at room temperature for 5 h. Evaporation followed by chromatography gave 1-trimethylsilyl-2-phenylacetylene as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06919322B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-ffe0ecb2f0ab46fcb30a1d500336098a |
| Source note | uspto-grants-2005_07 |