4-Methoxyphenol → HCID 69693963, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-methoxyphenol (12 grams, 52.4 mmol), 4-bromo-2-methylbenzoic acid methyl ester (12 grams, 52 mmol), potassium carbonate (14.5 grams, 105 mmol) and copper powder (3.3 grams, 52 mmol) was stirred at 200° C. for 12 hours. The mixture was cooled to 25° C., diluted with diethylether, and the organic phase was washed twice with water, dried over magnesium sulfate, filtered and concentrated in vacuo. Purification by silica gel chromatography (5% ether in hexanes) afforded 4.0 grams of 4-(4-Methoxy-phenoxy)-2-methyl-benzoic acid methyl ester. MS: 273.2 [M+H]+

Provenance & Evidence