L-Methionine → HCID 22349423, compound

Participants

Reaction Steps

A solution of 5-(4-Methoxy-phenoxy)-1-pyridin-3-yl-1H-indazole (0.11 grams, mmol) in 2 mL of methanesulfonic acid was treated with 0.2 grams of methionine. After stirring for 24 hours at room temperature, the mixture was treated with 1.2 grams of sodium hydroxide in 50 mL of water with cooling in an ice bath, neutralized with aqueous sodium bicarbonate, extracted 3 times with ethyl acetate, and the combined organic layers were dried over sodium sulfate, filtered and concentrated in vacuo, affording 0.10 grams of 4-(1-Pyridin-3-yl-1H-indazol-5-yloxy)-phenol as a colorless syrup. MS: 304.4 [M+H]+

Provenance & Evidence