L-Methionine → HCID 22349418, compound

Participants

Reaction Steps

A mixture of 1-(4-Fluoro-phenyl)-5-(4-methoxy-phenoxy)-1H-indazole (0.3 grams, mmol), methionine (0.40 grams, mmol) and 3 mL of methanesulfonic acid was shaken for 24 hours at room temperature. The mixture was treated with a solution of 1.8 grams of sodium hydroxide in 20 mL of water with cooling in an ice bath, and the aqueous phase was extracted 3 times with ethyl acetate. The combined organic phases were dried over sodium sulfate, filtered and concentrated in vacuo, affording 0.20 grams of 4-[1-(4-Fluoro-phenyl)-1H-indazol-5-yloxy]-phenol as a colorless solid. MS: 321.7 [M+H]+

Provenance & Evidence