L-Methionine → HCID 22349445, compound

Participants

Reaction Steps

A solution of 1-Isopropyl-5-(4-methoxy-phenoxy)-1H-indazole (0.090 grams, mmol) in 2 mL of methanesulfonic acid was treated with 0.15 grams of methionine. After stirring for 24 hours at room temperature, the mixture was treated with 1.2 grams of sodium hydroxide in 25 mL of water with cooling in an ice bath, neutralized with aqueous sodium bicarbonate, extracted 3 times with ethyl acetate, and the combined organic layers were dried over sodium sulfate, filtered and concentrated in vacuo, affording 0.090 grams of 4-(1-isopropyl-1H-indazol-5-yloxy)-phenol as a colorless syrup. MS: 269.7 [M+H]+

Provenance & Evidence