3-Chloroaniline → HCID 9878858, compound

Participants

Reaction Steps

To a solution of 6-(chloromethyl-4-methylthio-1,3,5-triazine-2-ylamine (75 mg, 0.39 mmol) in dry tetrahydrofuran (3 mL) was added a solution of 3-chloroaniline (0.210 mL, 1.97 mmol) in dry tetrahydrofuran (1 mL) followed by anhydrous N,N-diisopropylethylamine (0.343 mL, 1.95 mmol). The mixture was heated under reflux for 16 hours, after which the solvent was evaporated. The residue was purified by reverse phase HPLC to give 4-[(3-chlorophenylamino)methyl]-6-methylthio-[1,3,5]triazin-2-ylamine. M+1=266.1.

Provenance & Evidence