Pyridine, 4-(trimethylstannyl)- → [6-(2,4-Difluoro-phenylamino)-pyridin-3-yl]-(2-methoxy-5-pyridin-4-yl-phenyl)-methanone

Participants

Reaction Steps

(5-Bromo-2-methoxy-phenyl)-[6-(2,4-difluoro-phenylamino)-pyridin-3-yl]-methanone (100 mg; 0.24 mmol), 4-trimethylstannylpyridine (115 mg; 0.47 mml) and PdCl2(PPh3)2 (50 mg; 0.07 mmol) are dissolved in xylene (2 ml) and refluxed under argon for 20 min. The reaction mixture is purified via chromatography (SiO2; acetone/hexanes 3/7) and yields the title compound as a colorless foam (32 mg; 32%).

Provenance & Evidence