反应详情

(2-Chloro-5-pyridin-4-yl-phenyl)-[6-(2,4-difluoro-phenylamino)-pyridin-3-yl]-methanol (111 mg; 0.26 mmol) is dissolved in acetone (20 ml) and treated with Jones reagent (0.45 ml; 1 mmol) for 20 min at room temperature. 2N Na2CO3 is added to the reaction mixture and extracted with ethyl acetate three times. The combined organic phases are dried over Na2SO4 and evaporated to dryness. Purification via chromatography (SiO2; CH2Cl2/MeOH 98/2) provides the title compound as a slightly colored foam (30 mg; 27%).

1. extractionextracted with ethyl acetate three times
2. dry with materialThe combined organic phases are dried over Na2SO4
3. customevaporated to dryness
4. customPurification via chromatography (SiO2; CH2Cl2/MeOH 98/2)