Sodium Carbonate → HCID 20814258, compound

Participants

Reaction Steps

2-Chloro-4-(1-piperazinyl)benzaldehyde (4) (560 mg; 2.5 mmol) is dissolved in THF (20 ml), ClCO2Et (500 mg; 4.5 mmol) and 2N Na2CO3 (20 ml) added and the reaction mixture stirred at room temperature for 20 min. The mixture is extracted with TBME three times, the combined organic phases are dried over Na2SO4 and evaporated to dryness yielding the title compound as white crystals (700 mg; 94%).

Provenance & Evidence