1-methyl-4-((E)-2-tributylstannanyl-vinyl)-piperidin-4-ol → HCID 22349582, compound

HRID 896093Notes

Reaction equation

HRID 896093 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([O:25][CH3:26])=[C:6]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:18]=3[F:24])=[CH:12][CH:11]=2)=[O:9])[CH:7]=1.[CH3:27][N:28]1[CH2:33][CH2:32][C:31](/[CH:35]=[CH:36]/[Sn](CCCC)(CCCC)CCCC)([OH:34])[CH2:30][CH2:29]1>>[F:24][C:18]1[CH:19]=[C:20]([F:23])[CH:21]=[CH:22][C:17]=1[NH:16][C:13]1[CH:14]=[CH:15][C:10]([C:8]([C:6]2[CH:7]=[C:2](/[CH:36]=[CH:35]/[C:31]3([OH:34])[CH2:32][CH2:33][N:28]([CH3:27])[CH2:29][CH2:30]3)[CH:3]=[CH:4][C:5]=2[O:25][CH3:26])=[O:9])=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 223495731-methyl-4-((E)-2-tributylstannanyl-vinyl)-piperidin-4-olHCID 22349575(5-Bromo-2-methoxy-phenyl)-[4-(2,4-difluoro-phenylamino)-phenyl]-methanone

Product 1

HCID 22349582HCID 22349582, compound

Procedure

The title compound is prepared analogously to example 9 from (5-bromo-2-methoxy-phenyl)-[4-(2,4-difluoro-phenylamino)-phenyl]-methanone and 1-methyl-4-((E)-2-tributylstannanyl-vinyl)-piperidin-4-ol.

Sources & evidence

ORD record
ord-31e93a6549bb422aa98efdb8909515c6
Source dataset
uspto-grants-2005_07
Patent number
US06919336B2

Reaction notes

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