Ammonia → HCID 21877717, compound

HRID 896195Notes

Reaction equation

C[O:2][C:3]([C@@H:5]1[O:9][C:8](=[O:10])[N:7]([C:11]2[CH:22]=[CH:21][C:14]3[N:15]([CH3:20])[C:16](=[S:19])[CH2:17][S:18][C:13]=3[CH:12]=2)[CH2:6]1)=O.[NH3:23]>CO>[CH3:20][N:15]1[C:14]2[CH:21]=[CH:22][C:11]([N:7]3[CH2:6][CH:5]([C:3]([NH2:23])=[O:2])[O:9][C:8]3=[O:10])=[CH:12][C:13]=2[S:18][CH2:17][C:16]1=[S:19]

Participants

Conditions

Temperature: 40 °C

Procedure

To a stirred suspension of (5R)-3-(3,4-dihydro-4-methyl-3-thioxo-2H-1,4-benzothiazin-7-yl)-2-oxo-5-oxazolidinecarboxylic acid methyl ester (Step 1, 100 mg, 0.2955 mmol) in MeOH (3 mL) is added 2.0 M ammonia in MeOH (1.0 mL). This mixture is heated at 40° C. for 24 h at which time the reaction is concentrated under reduced pressure. The residue is washed with MeOH (4 mL) and purified by column chromatography (2% MeOH/CH2Cl2) to give the title compound as a white solid (25 mg, 26%), 1H NMR (300 MHz, DMSO) δ 7.87 (br s, 1H), 7.64 (d, 2H), 7.51 (s, 2H), 5.03 (dd, 1H), 4.28 (t, 1H), 4.02 (dd, 1H), 3.85 (s, 2H), 3.32 (s, 3H); MS for C13H13N3O3S2 m/z 324.5 (M+H)+.

Workup

concentrationis concentrated under reduced pressure
washThe residue is washed with MeOH (4 mL)
custompurified by column chromatography (2% MeOH/CH2Cl2)

Sources & evidence

ORD record: ord-d395045652314928a6811edaaeb6a815
Source dataset: uspto-grants-2005_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06919329B2

Reaction notes

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