2-Tert-butyl-4-[4-(3-chloro-propyl)-piperazin-1-yl]-6-propyl-pyrimidine → 2-tert-Butyl-4-{4-[3-(4-methyl-5-methyl-4H-[1,2,4]triazol-3-ylsulfanyl)-propyl]-piperazin-1-yl}-6-propyl-pyrimidine hydrochloride

HRID 896223Notes

Reaction equation

HRID 896223 reaction equation
[C:1]([C:5]1[N:10]=[C:9]([N:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][Cl:20])[CH2:13][CH2:12]2)[CH:8]=[C:7]([CH2:21][CH2:22][CH3:23])[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:24][N:25]1[C:29]([CH3:30])=[N:28][N:27]=[C:26]1[SH:31]>>[ClH:20].[C:1]([C:5]1[N:10]=[C:9]([N:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][S:31][C:26]3[N:25]([CH3:24])[C:29]([CH3:30])=[N:28][N:27]=3)[CH2:13][CH2:12]2)[CH:8]=[C:7]([CH2:21][CH2:22][CH3:23])[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 223498642-Tert-butyl-4-[4-(3-chloro-propyl)-piperazin-1-yl]-6-propyl-pyrimidineHCID 178434152HCID 178434152, compound

Product 1

HCID 115472512-tert-Butyl-4-{4-[3-(4-methyl-5-methyl-4H-[1,2,4]triazol-3-ylsulfanyl)-propyl]-piperazin-1-yl}-6-propyl-pyrimidine hydrochlorideYield 36.2%

Procedure

Reaction of 1 g of 2-tert-butyl-4-[4-(3-chloro-propyl)-piperazin-1-yl]-6-propyl-pyrimidine (2.95 mmol) with 0.42 g of 4-methyl-5-methyl-4H-[1,2,4]triazole-3-thiol (3.25 mmol) yielded 0.5 g (33.6%) of title compound as a solid.

Sources & evidence

ORD record
ord-a841aeefdc024bc9b92b3c2050bdba32
Source dataset
uspto-grants-2005_07
Patent number
US06919342B2

Reaction notes

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